Hypercalcemia can lead to altered mental status in people with vitamin D toxicity. Share on Pinterest Alina Hvostikova/Stocksy Altered mental status If you take large doses of vitamin D, you may experience stomach pain, loss of appetite, constipation, or diarrhea as a result of elevated calcium levels. Taking vitamin D can increase levels of calcium in the blood, and too much calcium can cause side effects. These symptoms resolved after the child stopped taking the supplements ( 15). Importantly, these symptoms occurred in response to extremely high doses of vitamin D3, which led to calcium levels greater than 12 mg/dL.įor example, an 18-month-old child who was given 50,000 IU of vitamin D3 for 3 months experienced diarrhea, stomach pain, and other symptoms. One woman experienced nausea and weight loss after taking a supplement that was later found to contain 78 times more vitamin D than stated on the label ( 14). However, not all people with hypercalcemia experience the exact same symptoms. Some of the main symptoms of hypercalcemia include: The main side effects of excessive vitamin D levels are related to excessive calcium in the blood ( 13). Taking too much vitamin D may result in excessive absorption of calcium, which can cause several potentially dangerous symptoms. Hypercalcemia can be life threatening and requires immediate medical attention. Her blood calcium levels were 3.23 mmol/L (12.9 mg/dL) ( 12). These included nausea, vomiting, muscle weakness, and kidney injury.
In the 2020 case report mentioned earlier, the woman who took an average of 130,000 IU of vitamin D per day for 20 months was also hospitalized for symptoms related to hypercalcemia ( 12). Research shows that adults taking more than 10,000 IU of vitamin D daily who exhibit symptoms should be evaluated for hypercalcemia ( 11). Hypercalcemia typically develops after people take megadoses of vitamin D for a prolonged period of time. The normal range of blood calcium is 8.5–10.8 mg/dL ( 9, 10). high blood pressure and heart abnormalities.kidney stones, kidney injury, and even kidney failure.
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However, make sure to consult a healthcare professional on what dosage you should take. Keep in mind that people who are low or deficient in vitamin D may need to take much higher levels than the safe upper limit to reach and maintain optimal vitamin D levels. Her vitamin D levels were discovered to be 265 ng/mL, which equals 130,000 IU and is over 30 times the generally recommended safe upper limit of 4,000 IU per day ( 7). In another 2020 case report, a 56-year-old woman who took an average of 130,000 IU of vitamin D per day for 20 months in hopes of improving symptoms of multiple sclerosis was hospitalized for symptoms including nausea, vomiting, and muscle weakness. Most cases of vitamin D toxicity are caused by inappropriate supplement dosing and prescription errors.įor example, in a 2020 case report, a 73-year-old man developed vitamin D toxicity after taking 10,000 IU of vitamin D per day for many years ( 6). Recommendations on optimal vitamin D levels vary, but research suggests that levels between 30–60 ng/mL are likely optimal and may help protect against illness and disease ( 4, 5).Įven when taking high dose vitamin D supplements, it’s unlikely that a healthy person’s blood vitamin D levels would come close to reaching excessive or toxic levels. Hypervitaminosis D is defined as blood vitamin D levels over 100 ng/mL, while vitamin D intoxication is defined as serum levels over 150 ng/mL ( 3, 4).
In order for vitamin D to reach toxic or dangerous levels in the body, it needs to exceed 100 nanograms (ng) per milliliter (mL). Signs of too much vitamin D include: Elevated blood levels What are the symptoms of vitamin D toxicity?
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